Attention deficit hyperactivity disorder may be a highly inflammation and immune-associated disease (Review)

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Rong-Yi Zhou1, Jiao-Jiao Wang1, Ji-Chao Sun1

  • 1First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China.

Molecular Medicine Reports
|August 30, 2017
PubMed

Insights

Attention deficit hyperactivity disorder (ADHD) may be linked to immune system dysfunction and inflammation. This research explores the potential connection between ADHD and allergic diseases, suggesting new avenues for understanding its causes.

Area of Science:

  • Pediatrics
  • Immunology
  • Neurodevelopmental Disorders

Background:

  • Attention deficit hyperactivity disorder (ADHD) is a prevalent behavioral disorder.
  • Existing research suggests links between ADHD and genetic, environmental, and lifestyle factors.
  • A notable observation in China is the co-occurrence of ADHD with allergic rhinitis or asthma in many children.

Purpose of the Study:

  • To investigate the potential association between ADHD and allergic diseases.
  • To test the hypothesis that ADHD is a high inflammation and immune-associated disorder.
  • To explore immune system disorders as a potential component of ADHD etiology.

Main Methods:

  • Clinical observations of children with ADHD and allergic conditions.
  • Review of previous studies on ADHD and allergic diseases.
  • Design of future clinical and animal experiments to validate the hypothesis.

Main Results:

  • Children with ADHD and allergic conditions exhibit increased susceptibility to respiratory infections.
  • Respiratory infections can exacerbate ADHD symptoms or lead to recurrence.
  • Previous studies indicate a close association between ADHD and allergic diseases.

Conclusions:

  • ADHD may be closely associated with allergic diseases and immune system disorders.
  • Immune system dysfunction could represent a novel aspect of ADHD etiology.
  • This research may inform future clinical practices for managing ADHD.

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