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Updated: Feb 23, 2026

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
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Kidins220 and tumour development: Insights into a complexity of cross-talk among signalling pathways (Review)

Shuo Cai1, Jun Cai1, Wen G Jiang1

  • 1Cardiff China Medical Research Collaborative, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, CF14 4XN, UK.

International Journal of Molecular Medicine
|August 30, 2017
PubMed

Insights

Kinase D-interacting substrate of 220 kDa/ankyrin repeat-rich membrane spanning (Kidins220/ARMS) is crucial for neuronal functions and vascular development. This review explores Kidins220

Area of Science:

  • Molecular and Cellular Biology
  • Oncology
  • Neuroscience
  • Cardiovascular Biology

Background:

  • Kinase D-interacting substrate of 220 kDa/ankyrin repeat-rich membrane spanning (Kidins220/ARMS) is a key protein involved in integrating cellular signals.
  • Kidins220/ARMS mediates essential neuronal activities including differentiation, survival, and cytoskeleton remodeling.
  • Evidence suggests Kidins220/ARMS also plays roles in vascular development, immunomodulation, and is implicated in various malignancies.

Purpose of the Study:

  • To review recent advancements in understanding Kidins220/ARMS.
  • To elucidate the role of Kidins220/ARMS in cancer development and progression.
  • To highlight the protein's involvement in cytoskeleton dynamics and epithelial-mesenchymal transition (EMT) in cancer.

Main Methods:

  • Literature review of recent studies on Kidins220/ARMS.
  • Analysis of existing data on Kidins220/ARMS function in neuronal, vascular, and immune systems.
  • Examination of evidence linking Kidins220/ARMS to cancer biology, including tumorigenesis and metastasis.

Main Results:

  • Kidins220/ARMS is a multifunctional protein with established roles in neuronal development and cardiovascular health.
  • Kidins220/ARMS influences immune responses through interactions with B and T cells.
  • Growing evidence implicates Kidins220/ARMS in the regulation of multiple cellular processes critical to cancer development.

Conclusions:

  • Kidins220/ARMS is a significant protein with diverse biological functions.
  • Further research is needed to fully understand Kidins220/ARMS's role in cancer, particularly its influence on cytoskeleton dynamics, EMT, and tumor progression.
  • Investigating Kidins220/ARMS may reveal novel therapeutic targets for cancer treatment.

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