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Updated: Feb 23, 2026

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
[Gender confirming surgery : Female-to-male and male-to-female]
M Sohn1, U M Rieger2, J Heß3
1Klinik für Urologie, Agaplesion Markus-Krankenhaus, Frankfurt am Main, Deutschland.
Gender confirming surgery (GCS) is an evolving urological specialty. This review summarizes interdisciplinary strategies for male-to-female (MtF) and female-to-male (FtM) GCS, highlighting high satisfaction rates and preferred surgical techniques.
Area of Science:
- Urology
- Gender Affirming Surgery
- Surgical Management
Background:
- Gender confirming surgery (GCS) is a developing interdisciplinary field within urology.
- This review focuses on surgical strategies for male-to-female (MtF) and female-to-male (FtM) gender confirmation.
Purpose of the Study:
- To summarize the development of interdisciplinary strategies in GCS based on over 20 years of surgical experience.
- To present aspects of GCS relevant to urologists.
Main Methods:
- Comprehensive review of national and international literature on GCS.
- Evaluation of authors' extensive surgical experience in performing GCS procedures.
Main Results:
- Over 1200 primary MtF GCS and 230 primary FtM GCS performed since 1990.
- High complication and secondary procedure rates in MtF GCS necessitate specialized interdisciplinary teams.
- Patient numbers for GCS are limited, with an estimated incidence of at least 1:20,000 for gender dysphoria.
Conclusions:
- Postoperative satisfaction rates exceed 80% for both FtM and MtF individuals.
- Surgical procedures for GCS have become increasingly standardized over recent decades.
- The free forearm flap is the preferred method for penile reconstruction, though alternatives exist.
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