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Related Experiment Videos

Further evidence to support the alpha 2-adrenergic nature of amitraz-induced decrease in intestinal motility.

W H Hsu, R N Shaw, D D Schaffer

    Archives Internationales De Pharmacodynamie Et De Therapie
    |March 1, 1987
    PubMed
    Summary

    Amitraz, an insecticide, inhibits guinea-pig intestinal contractions by activating alpha 2-adrenoceptors. This action reduces parasympathetic tone in the myenteric plexus, affecting gut motility.

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    Area of Science:

    • Pharmacology
    • Neurogastroenterology
    • Insecticide Toxicology

    Background:

    • Insecticides can affect non-target organisms, including mammals.
    • The gastrointestinal system's motility is regulated by the autonomic nervous system.
    • Alpha-adrenoceptors play a role in modulating intestinal function.

    Purpose of the Study:

    • To investigate the effect of the formamidine insecticide amitraz on in vitro intestinal contractions.
    • To determine the specific adrenoceptor subtypes involved in amitraz's action on the gut.

    Main Methods:

    • Using transmurally-stimulated guinea-pig ileum preparations.
    • Administering amitraz in varying concentrations (10(-7) to 10(-6) M).
    • Utilizing alpha-adrenoceptor antagonists (idazoxan and prazosin) to probe receptor involvement.

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    Main Results:

    • Amitraz caused a dose-dependent inhibition of electrically-induced intestinal contractions.
    • Idazoxan (an alpha 2-adrenoceptor antagonist) blocked and reversed amitraz's inhibitory effect.
    • Prazosin (an alpha 1-adrenoceptor antagonist) did not prevent the effect of amitraz.

    Conclusions:

    • Alpha 2-adrenoceptors mediate the inhibitory effects of amitraz on guinea-pig ileum contractions.
    • Amitraz likely decreases intestinal contraction by activating alpha 2-adrenoceptors in the myenteric plexus.
    • This activation inhibits parasympathetic tone, leading to reduced gut motility.