Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Serum Laboratory Studies, Stool Test, Breath Test

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Improving colorectal polyp size classification with virtual scale endoscopy: implications for resection strategy and surveillance.

Gastrointestinal endoscopy·2026

Same author

Missing barrier in coeliac disease: why the gut vascular barrier matters.

Gut·2026

Same author

Optimizing bowel preparation regimens for colon capsule endoscopy: an umbrella review (overview of systematic reviews).

Therapeutic advances in gastrointestinal endoscopy·2026

Same author

Enhancing the Evidence: Critical Insights and Future Directions for Texture and Color Enhancement Imaging in Colorectal Neoplasia Detection.

JGH open : an open access journal of gastroenterology and hepatology·2026

Same author

Patient-Level Predictors of Procedural Success in Colon Capsule Endoscopy: A Systematic Review and Meta-Analysis.

Journal of gastroenterology and hepatology·2026

Same author

Non-visualized Ultrasonography Should Remain Indeterminate in Patency Capsule Localization.

DEN open·2026

Search research articles

Related Experiment Video

Updated: Feb 23, 2026

Bioluminescent Bacterial Imaging In Vivo

Bioluminescent Bacterial Imaging In Vivo

Published on: November 4, 2012

Luminally expressed gastrointestinal biomarkers.

Gerard Cummins¹, Diana E Yung², Ben F Cox³

¹a Institute of Sensors, Signals and Systems, School of Engineering and Physical Sciences , Heriot-Watt University , Edinburgh , UK.

Expert Review of Gastroenterology & Hepatology

|August 30, 2017

Summary

This review explores gastrointestinal biomarkers for inflammatory bowel disease and colorectal cancer. While some markers like faecal calprotectin are established, many lack sufficient sensitivity and specificity for widespread clinical use.

Keywords:

Biomarker faecal calprotectin faecal occult blood testing fatty acid binding proteins gastrointestinal disease lactoferrin microbiome mucins phagocyte derived protein volatilome

More Related Videos

Author Spotlight: Investigating the Effects of Compounds on Intestinal Tissue Using 3D Human Cell Line Models

Author Spotlight: Investigating the Effects of Compounds on Intestinal Tissue Using 3D Human Cell Line Models

Published on: September 1, 2023

Author Spotlight: Gastric Epithelial Cell Responses in Helicobacter pylori infection

Author Spotlight: Gastric Epithelial Cell Responses in Helicobacter pylori infection

Published on: July 5, 2024

Related Experiment Videos

Last Updated: Feb 23, 2026

Bioluminescent Bacterial Imaging In Vivo

Bioluminescent Bacterial Imaging In Vivo

Published on: November 4, 2012

Author Spotlight: Investigating the Effects of Compounds on Intestinal Tissue Using 3D Human Cell Line Models

Author Spotlight: Investigating the Effects of Compounds on Intestinal Tissue Using 3D Human Cell Line Models

Published on: September 1, 2023

Author Spotlight: Gastric Epithelial Cell Responses in Helicobacter pylori infection

Author Spotlight: Gastric Epithelial Cell Responses in Helicobacter pylori infection

Published on: July 5, 2024

Area of Science:

Gastroenterology
Biomarker Discovery
Oncology

Background:

Biomarkers are crucial indicators of biological processes, disease, and treatment response.
Identifying clinically useful biomarkers faces significant challenges before widespread adoption.
This review focuses on gastrointestinal biomarkers for inflammatory bowel disease (IBD) and colorectal cancer (CRC).

Purpose of the Study:

To provide a comprehensive overview of existing and emerging biomarkers for IBD and CRC.
To discuss the clinical utility and limitations of current biomarkers.
To highlight potential future biomarkers for improved diagnosis and monitoring.

Main Methods:

Literature review of established and novel biomarkers for gastrointestinal diseases.
Analysis of biomarkers including inflammatory markers (e.g., faecal calprotectin), malignancy markers (e.g., Stool DNA), and other indicators.
Inclusion of emerging markers such as microbiota, volatile organic compounds, and pH.

Main Results:

Several biomarkers are clinically accepted, including faecal calprotectin (FC), S100A12, and Fatty Acid Binding Proteins (FABP) for inflammation.
Malignancy markers such as Faecal Occult Blood, Mucins, and Stool DNA are also utilized.
Emerging biomarkers like faecal microRNA (miRNA), microbiota, and volatile organic compounds show promise but require further validation.

Conclusions:

Currently, few biomarkers like FC are fully validated for routine clinical use in gastrointestinal diseases.
Many existing biomarkers exhibit limitations in sensitivity and specificity.
Further research and validation are essential for emerging biomarkers to enhance the diagnosis and management of IBD and CRC.