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Updated: Feb 23, 2026

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates
Published on: February 17, 2023
Carbapenem-resistant Enterobacteriaceae in Pediatric Bloodstream Infections in Rural Southern India
Ramalingam Sekar1, Manoharan Mythreyee, Seetharaman Srivani
1Departments of Microbiology and *Pediatrics, Government Theni Medical College, The Tamilnadu Dr MGR Medical University, Theni; and #Department of Microbiology, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai; India. Correspondence to: Dr Ramalingam Sekar, Assistant Professor of Microbiology, Government Theni Medical College, Theni, India. sekaralingam@gmail.com.
Objective:
To measure the frequency of antimicrobial resistance in pediatric blood culture isolates of Escherichia coli and Klebsiella spp. with focus on carbapenem resistance.
Methods:
Over a period of three years, pediatric blood culture isolates were tested for antimicrobial susceptibility, including molecular investigations for carbapenem resistance.
Results:
Amikacin, carbapenems, colistin and tigecycline had an antimicrobial efficacy of >70% (n=140). 7 of the 15 randomly selected isolates were positive for carbapenemase gene; among them, five were New Delhi Metallo b-lactamase (NDM).
Conclusion:
There was a high prevalence of Klebsiella spp. in pediatric bacteremia and dissemination of NDM-mediated carbapenem resistance in pediatric wards.
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