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Supramolecular catalysis and dynamic assemblies for medicine.

Zhaoqianqi Feng1, Tengfei Zhang, Huaimin Wang

  • 1Department of Chemistry, Brandeis University, 415 South Street, Waltham, MA 02453, USA.

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This review explores supramolecular catalysis and dynamic assemblies, focusing on self-assembly and disassembly for medical applications. Research advances in molecular imaging and anticancer therapeutics are highlighted.

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Area of Science:

  • Supramolecular Chemistry
  • Chemical Biology
  • Materials Science

Background:

  • Cells utilize supramolecular catalysis and dynamic assemblies for intricate functions.
  • Dynamic assemblies are crucial for biological processes, forming and reversibly dissipating.
  • Self-assembly of small molecules has advanced, but disassembly remains less explored.

Purpose of the Study:

  • To review the regulation of dynamic assemblies via self-assembly and disassembly processes.
  • To highlight applications in therapeutics and diagnostics.
  • To provide a perspective on future research directions.

Main Methods:

  • Discussing cellular mechanisms of self-assembly and disassembly.
  • Describing recent advances in designing and regulating small molecule assemblies.
  • Focusing on applications in molecular imaging and anticancer therapeutics.

Main Results:

  • Progress in dynamic generation of supramolecular assemblies.
  • Underexplored disassembly processes identified.
  • Key advances in designing self-assembly/disassembly for medical uses.

Conclusions:

  • Dynamic assemblies offer significant potential for medical applications.
  • Controlling both assembly and disassembly is key for therapeutic and diagnostic development.
  • Future research should focus on integrating these principles for advanced medicine.