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Updated: Feb 23, 2026

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma
Published on: March 13, 2013
Ecology of melanoma cell
Lukáš Lacina1,2,3, Ondřej Kodet1,2,3, Barbora Dvořánková1,2
1Charles University, First Faculty of Medicine, Institute of Anatomy, Prague, Czech Republic.
Abstract:
Melanoma represents a cancer with increasing incidence worldwide and limited curability of advanced stages of the disease. Similarly to other types of tumors, the microenvironment is an important factor that participates in the control of melanoma biological properties. This review summarizes data regarding the role of the microenvironment, namely fibroblasts, keratinocytes and infiltrating immune cells, on melanoma growth and spreading. The role of embryonic microenvironment on melanoma cell biological properties is also discussed. The potential of therapeutic targeting of the melanoma microenvironment is demonstrated.
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