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Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

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Same author

Risk of Recurrent Coronary Events in Patients With Familial Hypercholesterolemia; A 10-Years Prospective Study.

Frontiers in pharmacology·2021
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Reducing the Clinical and Public Health Burden of Familial Hypercholesterolemia: A Global Call to Action.

JAMA cardiology·2020
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Impact of age on excess risk of coronary heart disease in patients with familial hypercholesterolaemia.

Heart (British Cardiac Society)·2018
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Cardiovascular disease mortality in patients with genetically verified familial hypercholesterolemia in Norway during 1992-2013.

European journal of preventive cardiology·2016
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Cardiovascular disease in patients with genotyped familial hypercholesterolemia in Norway during 1994-2009, a registry study.

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Dietary counseling is associated with an improved lipid profile in children with familial hypercholesterolemia.

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Related Experiment Video

Updated: Feb 23, 2026

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
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An update on familial hypercholesterolaemia.

Leiv Ose1

  • 1a Lipid Clinic , Rikshospitalet , Oslo , Norway .

Annals of Medicine
|August 30, 2017
PubMed
Summary

Familial hypercholesterolaemia (FH) is a genetic condition. This review covers FH diagnosis, treatment for adults and children, and family screening, emphasizing government cooperation for better management.

Area of Science:

  • Genetics and Public Health

Background:

  • Familial hypercholesterolaemia (FH) is an inherited disorder characterized by high cholesterol levels.
  • Early diagnosis and management are crucial for preventing cardiovascular complications.

Purpose of the Study:

  • To review a World Health Organization (WHO) consultation report on Familial Hypercholesterolaemia (FH).
  • To summarize key aspects of FH including diagnosis, treatment, and public health strategies.

Main Methods:

  • Review of a WHO consultation report on FH.
  • Synthesis of information on molecular basis, diagnosis, treatment, and psychosocial aspects.

Main Results:

  • The WHO report updates on FH molecular basis and DNA diagnosis.
  • It details clinical criteria, treatment for adults and children, and the role of diet.
Keywords:
DNA diagnosischildrenfamilial hypercholesterolaemialow-density lipoprotein cholesterollow-density lipoprotein receptor

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  • The report also addresses psychosocial factors, cascade screening, and governmental roles.

    • Conclusions:

    • Comprehensive management of FH requires a multi-faceted approach.
    • International collaboration and government support are vital for effective FH control programs.