Related Experiment Video
Updated: Feb 23, 2026
13:04
In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose
Published on: October 14, 2015
14.0K
Breast cancer and pregnancy
Laura Knabben1, Michel D Mueller2
1Department of Obstetrics and Gynaecology, University Hospital of Berne, Effingerstrasse 102, 3010 Berne, Switzerland, Phone: +41 31 632 10 10, Fax: +41 31 632 12 05.
Hormone Molecular Biology and Clinical Investigation
|August 30, 2017
Summary
Pregnancy-associated breast cancer (PABC) management requires multidisciplinary care. Diagnosis and treatment should align with non-pregnant guidelines, with chemotherapy possible after the first trimester, while radiotherapy and certain targeted therapies are contraindicated.
Area of Science:
- Oncology
- Reproductive Medicine
- Obstetrics
Background:
- Rising incidence of pregnancy-associated breast cancer (PABC) linked to delayed childbearing and increased breast cancer rates.
- PABC presents unique challenges in diagnosis and treatment due to pregnancy.
- Growing interest in fertility preservation and prognosis for patients diagnosed with breast cancer during or after pregnancy.
Purpose of the Study:
- To provide a comprehensive overview of PABC, including incidence, diagnosis, and treatment.
- To discuss management strategies for breast cancer during pregnancy and pregnancy after breast cancer diagnosis.
- To evaluate the impact of pregnancy on breast cancer prognosis and vice versa.
Main Methods:
- Systematic literature review.
- Analysis of incidence, diagnostic modalities, treatment protocols, and prognostic factors for PABC.
- Review of fertility preservation options and outcomes for pregnancy following breast cancer.
Main Results:
- Ultrasound is the preferred imaging; mammography is safe. Biopsy is crucial for indeterminate sonographic findings.
- Treatment should mirror non-pregnant guidelines; chemotherapy is feasible post-first trimester. Radiotherapy, trastuzumab, and tamoxifen are contraindicated.
- Pregnancy does not negatively affect breast cancer prognosis. Fertility preservation counseling is vital for young patients.
Conclusions:
- Multidisciplinary management is essential for PABC.
- Optimizing obstetric outcomes by avoiding preterm delivery is crucial.
- Further data collection is needed to enhance PABC management strategies.
Related Concept Videos
01:24Disorders of the Female Reproductive System
4.6K
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
4.6K
02:59Cancer Prevention
8.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
8.2K
02:07Tumor Progression
7.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.5K
01:07Teratogenicity
4.3K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.3K
01:19Psychoneuroimmunology: Diabetes and Cancer
542
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
542
02:18Cancer
54.8K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
54.8K