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A randomized controlled trial of corticosteroids for pain after transoral robotic surgery
Daniel Clayburgh1, Will Stott1, Rachel Bolognone1
1Department of Otolaryngology-Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon.
Objective:
To determine if an extended perioperative course of corticosteroids will improve pain control following transoral robotic surgery (TORS).
Study Design:
Randomized, double-blind, placebo-controlled trial.
Methods:
Patients undergoing TORS for initial treatment of oropharyngeal squamous cell carcinoma received a single intraoperative dose of 10-mg dexamethasone and then were randomized to receive 8-mg dexamethasone every 8 hours, or placebo, for up to 4 days after surgery. Pain, measured by visual analog scale (VAS), was the primary outcome measure. Secondary outcome measures included length of stay, dysphagia assessments, and complications.
Results:
VAS pain scores were similar between steroid and placebo cohorts on postoperative day (POD) 1, 2, and 7 through 21, although they significantly improved in the steroid cohort on POD 3. The steroid cohort also demonstrated a decreased hospital length of stay (median 1 day) and improvement in diet consistency, as measured by the performance status scale on POD 7 through 21. There was no difference in complications between the steroid and placebo cohorts.
Conclusion:
Extended perioperative corticosteroids after TORS is safe and may allow earlier improvement in diet consistency and decreased length of hospital stay, although postoperative pain appears minimally affected.
Level Of Evidence:
1b. Laryngoscope, 127:2558-2564, 2017.
