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Elevated PT, APPT and PT/INR possibly associated with doxycycline and cefoperazone co-administration: A case report

X Q Zhu1, C F Guo2, Y G Wen1

  • 1Department of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.

Journal of Clinical Pharmacy and Therapeutics
|August 30, 2017
PubMed
Abstract

Insights

This case study highlights potential blood coagulation changes when doxycycline and cefoperazone are used together. Monitoring prothrombin time (PT), activated partial thromboplastin time (APPT), and PT/INR is recommended.

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Hematology

Background:

  • Limited data exists on the impact of tetracycline antibiotics on blood coagulation.
  • Co-administration of antibiotics requires careful consideration of potential drug interactions and patient outcomes.

Observation:

  • An 83-year-old male patient with severe pneumonia, renal insufficiency, and malnutrition presented with elevated PT, APPT, and PT/INR.
  • These coagulation abnormalities emerged shortly after the initiation of doxycycline in conjunction with cefoperazone therapy.

Findings:

  • The elevated PT, APPT, and PT/INR normalized upon discontinuation of doxycycline.
  • This suggests a potential causal link between doxycycline and cefoperazone co-administration and altered coagulation parameters.

Implications:

  • Close monitoring of coagulation parameters (PT, APPT, PT/INR) is advisable for patients receiving concurrent doxycycline and cefoperazone.
  • Further research is warranted to elucidate the mechanisms behind this observed interaction and its clinical significance.
Keywords:
case reportcefoperazonecoagulation parametersdoxycyclinedrug-drug interaction

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