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Related Concept Videos

Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

44
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
44
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

58
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
58
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

54
Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
54
Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

47
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
47
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

64
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
64
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

2.0K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
2.0K

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Related Experiment Video

Updated: Feb 23, 2026

Utilizing an Orally Dissolving Strip for Pharmacological and Toxicological Studies: A Simple and Humane Alternative to Oral Gavage for Animals
04:28

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Intestinal patch systems for oral drug delivery.

Amrita Banerjee1, Samir Mitragotri2

  • 1Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA.

Current Opinion in Pharmacology
|August 30, 2017
PubMed
Summary

Intestinal patches offer a needle-free oral drug delivery method for medications with poor bioavailability, improving patient quality of life. This technology enhances drug absorption and controlled release in the gastrointestinal tract.

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Area of Science:

  • Pharmaceutics
  • Drug Delivery Systems
  • Gastroenterology

Background:

  • Many drugs with poor oral bioavailability require injections, impacting patient compliance and quality of life.
  • Current delivery methods face challenges like drug degradation and poor absorption in the gastrointestinal tract.

Purpose of the Study:

  • To explore intestinal patches as a novel platform for oral drug delivery.
  • To overcome limitations of injectable drug administration for chronic conditions.

Main Methods:

  • Development of intestinal patch-based devices for localized drug delivery.
  • Utilizing the gastrointestinal tract for enhanced drug absorption and controlled release.

Main Results:

  • Intestinal patches prevent drug degradation and luminal loss.
  • Localized drug depots facilitate intestinal absorption and unidirectional release.
  • Successful application in delivering drugs like insulin, exenatide, and erythropoietin.

Conclusions:

  • Intestinal patch technology presents a promising needle-free alternative to injections.
  • This approach can significantly improve the quality of life for patients requiring chronic drug administration.