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[Cancer and nutrition - a paradigma shift]
R Imoberdorf1, M Rühlin2, P E Ballmer1
1Klinik für Innere Medizin, Departement Medizin.
Laryngo- Rhino- Otologie
|August 30, 2017
Summary
Cancer patients often suffer from malnutrition, impacting treatment outcomes. Emerging evidence suggests a high-fat, high-protein diet may be beneficial, challenging traditional nutritional advice for cancer care.
Area of Science:
- Oncology
- Nutritional Science
- Cancer Biology
Background:
- International variations in cancer prevalence suggest nutrition plays a key role.
- Nutritional factors may account for up to 35% of malignant tumor development.
- Patients frequently experience significant weight loss at diagnosis due to undernutrition and malnutrition.
Purpose of the Study:
- To investigate the role of nutrition in cancer development and patient outcomes.
- To explore the impact of cancer and its treatment on nutritional status.
- To evaluate the potential benefits of a high-fat, high-protein diet in cancer care.
Main Methods:
- Review of physiological, pathophysiological, genetic, and molecular biology of cancer metabolism.
- Analysis of evidence regarding nutritional factors in cancer development.
- Discussion of metabolic processes in cancer and their regulation.
Main Results:
- Cancer disease and treatments (e.g., chemotherapy, radiation) often lead to appetite loss, taste changes, nausea, and vomiting, exacerbating undernutrition.
- Undernutrition significantly affects disease prognosis and treatment tolerance.
- Growing evidence indicates a potentially favorable role for diets rich in fat and protein in cancer patients.
Conclusions:
- Nutritional support is crucial for cancer patients experiencing impaired intake.
- A paradigm shift may be necessary, moving from traditional balanced diets towards high-fat, high-protein approaches.
- Further evidence-based data is required to resolve the controversy surrounding this new dietary concept in cancer therapy.
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