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Related Concept Videos

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Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and...
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In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...
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Pattern II and pattern III MS are entities distinct from pattern I MS: evidence from cerebrospinal fluid analysis.

S Jarius1, F B König2, I Metz2

  • 1Molecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, Heidelberg, Germany. sven.jarius@med.uni-heidelberg.de.

Journal of Neuroinflammation
|August 31, 2017
PubMed
Summary

Multiple sclerosis (MS) exhibits distinct pathological patterns. Pattern II and III MS show differences in cerebrospinal fluid (CSF) findings compared to Pattern I MS, suggesting distinct disease entities.

Keywords:
Blood-CSF barrier dysfunctionCerebrospinal fluidHistopathologyIntrathecal IgG synthesisMultiple sclerosisOligoclonal bandsPattern I lesionsPattern II lesionsPattern III lesionsQAlbQIgGTotal protein

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Area of Science:

  • Neurology
  • Immunology
  • Pathology

Background:

  • Multiple sclerosis (MS) diagnosis relies on clinical and MRI data.
  • Histopathological studies reveal four MS lesion patterns, indicating potential heterogeneity.
  • This heterogeneity suggests MS may encompass distinct disease entities rather than a single condition.

Purpose of the Study:

  • To investigate differences in cerebrospinal fluid (CSF) findings between MS patterns.
  • To assess intrathecal IgG synthesis in relation to MS pathological patterns.
  • To differentiate MS patterns from mimics like aquaporin-4-IgG and myelin oligodendrocyte glycoprotein-IgG disorders.

Main Methods:

  • Retrospective analysis of 68 lumbar punctures from patients with classified MS patterns (I, II, III).
  • Evaluation of CSF findings, including oligoclonal bands (OCBs) and intrathecal IgG synthesis.
  • Assessment of blood-CSF barrier function using albumin CSF/serum ratio (QAlb).

Main Results:

  • Oligoclonal bands (OCBs) were significantly more prevalent in Pattern I MS (88.2%) than in Patterns II/III MS (27%).
  • Intrathecal IgG response (MRZ reaction) was absent in Pattern II/III MS patients.
  • Elevated albumin CSF/serum ratio (QAlb), indicating impaired blood-CSF barrier, was more frequent in Pattern II/III MS.

Conclusions:

  • Pattern II and III MS patients exhibit distinct CSF profiles compared to Pattern I MS.
  • Differences in intrathecal IgG synthesis and blood-CSF barrier function support distinct disease entities.
  • Findings support classifying Pattern II and III MS as separate from Pattern I MS.