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Related Experiment Video

Updated: Feb 23, 2026

Whole-Brain Single-Cell Imaging and Analysis of Intact Neonatal Mouse Brains Using MRI, Tissue Clearing, and Light-Sheet Microscopy
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Mapping White Matter Microstructure in the One Month Human Brain.

D C Dean1,2, E M Planalp3,4, W Wooten5

  • 1Waisman Center, University of Wisconsin-Madison, Madison, WI, USA. deaniii@wisc.edu.

Scientific Reports
|August 31, 2017
PubMed
Summary
This summary is machine-generated.

This study reveals early white matter microstructure development in infants using advanced imaging. These findings are crucial for understanding typical and atypical neurodevelopment in newborns.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Medical Imaging

Background:

  • White matter microstructure is vital for neural communication and undergoes significant development in early life.
  • Deviations in early neurodevelopment can impact brain connectivity and behavior.
  • Limited research exists on infant brain microstructure, especially in the first three months of life.

Purpose of the Study:

  • To investigate neonatal white matter microstructure in a cohort of 104 infants.
  • To establish normative data for early white matter development.
  • To explore associations between microstructure and factors like age, sex, and growth.

Main Methods:

  • Utilized quantitative diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI).
  • Developed an optimized multiple b-value diffusion protocol for non-sedated infant scans.
  • Assessed relationships between microstructure measures and clinical/demographic variables.

Main Results:

  • Observed significant changes in white matter microstructure during the earliest postnatal weeks.
  • Identified differential timing in the development of various brain regions and asymmetries.
  • Found associations between microstructure and factors such as corrected gestational age and infant sex.

Conclusions:

  • Neonatal white matter microstructure exhibits dynamic changes in the weeks following birth.
  • This research provides critical insights into normative neurodevelopmental trajectories.
  • Findings support the importance of early brain microstructure assessment for understanding developmental outcomes.