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An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons
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An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons

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BDNF pro-peptide: a novel synaptic modulator generated as an N-terminal fragment from the BDNF precursor by

Toshiyuki Mizui1,2, Koji Ohira3, Masami Kojima1,2,4

  • 1Biomedical Research Inst. (BMD), National Institute of Advanced Industrial Science and Technology (AIST), Osaka, Japan.

Neural Regeneration Research
|August 31, 2017
PubMed
Summary

The pro-domain of brain-derived neurotrophic factor (BDNF) can facilitate hippocampal long-term depression. A common BDNF Val66Met polymorphism affects this pro-peptide activity, influencing neural stem cell generation and ischemia.

Keywords:
BDNFgrowth factorischemianeural stem cellspeptide

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