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Updated: Feb 23, 2026
Controlled Cortical Impact Model for Traumatic Brain Injury
Published on: August 5, 2014
Spinal cord injury drives chronic brain changes
Ignacio Jure1, Florencia Labombarda1,2
1Laboratorio de Bioquímica Neuroendocrina, Instituto de Biología y Medicina Experimental, CONICET, Buenos Aires, Argentina.
Abstract:
Only a few studies have considered changes in brain structures other than sensory and motor cortex after spinal cord injury, although cognitive impairments have been reported in these patients. Spinal cord injury results in chronic brain neuroinflammation with consequent neurodegeneration and cognitive decline in rodents. Regarding the hippocampus, neurogenesis is reduced and reactive gliosis increased. These long-term abnormalities could explain behavioral impairments exhibited in humans patients suffering from spinal cord trauma.
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