Related Experiment Video
Updated: Feb 23, 2026
10:10
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
Published on: February 15, 2022
2.0K
Collapsing glomerulopathy: a 30-year perspective and single, large center experience.
L Nicholas Cossey1, Christopher P Larsen1, Helen Liapis1,2
1Renal Pathology Division, Arkana Laboratories, Little Rock, AR, USA.
Clinical Kidney Journal
|August 31, 2017
Summary
Collapsing glomerulopathy (CGP) is a kidney disease pattern often seen in those with African ancestry. Recent advances link CGP to genetic factors like APOL1 variants, shifting diagnosis towards molecular insights.
Area of Science:
- Nephrology
- Pathology
- Genetics
Background:
- Collapsing glomerulopathy (CGP) is a severe kidney injury pattern.
- It disproportionately affects individuals of African ancestry.
- CGP presents as rapidly progressive renal failure and nephrotic-range proteinuria.
Purpose of the Study:
- To review the evolution of collapsing glomerulopathy.
- To discuss its history, pathomechanisms, and disease spectrum.
- To emphasize the shift towards molecular diagnostics in CGP.
Main Methods:
- Review of historical data and clinical experience.
- Analysis of pathological findings in renal biopsies.
- Integration of genetic associations, including APOL1-risk variants.
Main Results:
- CGP has evolved from an HIV-associated diagnosis to one with diverse etiologies.
- Apolipoprotein L1 (APOL1)-risk variants are frequently implicated.
- Distinguishing CGP from mimics and linking histology to cause are crucial.
Conclusions:
- CGP diagnosis is increasingly incorporating molecular data beyond morphology.
- A comprehensive, molecular approach aids in risk stratification and personalized treatment.
- Further research into molecular pathways is needed for effective therapies.
More Related Videos
Related Concept Videos
01:29Acute Kidney Injury III: Clinical Manifestations
1.0K
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
1.0K
01:28Chronic Kidney Disease III: Interprofessional Care
503
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
503
01:26Nephrotic Syndrome II : Assessment and Medical Management
266
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
266
01:24Nephrotic Syndrome I : Introduction
727
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
727
01:25Glaucoma: Overview
1.5K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.5K
01:27Open Angle Glaucoma: Treatment
1.0K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.0K