Controlling ligand binding for tunable and switchable catalysis: cation-modulated hemilability in pincer-crown ether
1Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, USA. ajmm@email.unc.edu.
Abstract:
Methods for in situ reversible control over ligand binding processes at transition metal complexes can enable advances in switchable and tunable catalysis. After a brief overview of different approaches to controlling ligand binding, this Perspective details the development of "pincer-crown ether" ligands that contain a rigid pincer backbone and a hemilabile aza-crown ether unit that enables cation-modulated hemilability. Applications of pincer-crown ether complexes in small molecule activation and catalysis are discussed, culminating in a set of design principles for ligands capable of cation-modulated ligand binding.
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