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Altered Ethanol Consumption in Osteocalcin Null Mutant Mice.

Patricia Patterson-Buckendahl1, Muhammad Shahid2, Ankit Shah2

  • 1Center of Alcohol Studies, Rutgers, The State University of New Jersey, 607 Allison Road, Piscataway, NJ, 08854, USA. buckendp@smithers.rutgers.edu.

Cellular and Molecular Neurobiology
|August 31, 2017
PubMed
Summary
This summary is machine-generated.

Osteocalcin (OC) influences ethanol consumption under stress by modulating the adrenal catecholamine pathway. Mice lacking OC showed altered responses to stress and ethanol, suggesting OC

Keywords:
AdrenalCatecholamineGene expressionSensitizationTwo-bottle choice

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Area of Science:

  • Biochemistry
  • Neuroendocrinology
  • Behavioral Science

Background:

  • Osteocalcin (OC) is a bone-derived protein released into circulation.
  • Plasma OC levels are sensitive to stress hormones like glucocorticoids and catecholamines.
  • The relationship between OC, ethanol (EtOH) consumption, and stress is not fully understood.

Purpose of the Study:

  • To investigate the role of OC in modulating EtOH consumption and stress responses.
  • To compare EtOH intake and adrenal gene expression in mice with and without OC.
  • To explore OC's influence on the catecholamine synthetic pathway.

Main Methods:

  • Utilized wild-type (WT), heterozygous (HET), and osteocalcin null mutant (KO) mice.
  • Exposed mice to chronic unpredictable stress, EtOH consumption without stressors, and acute immobilization stress with EtOH.
  • Measured EtOH consumption and adrenal tyrosine-hydroxylase expression.

Main Results:

  • Significant differences in EtOH consumption were observed in mice exposed to various stressors.
  • Adrenal tyrosine-hydroxylase expression was inversely proportional to EtOH consumption.
  • KO mice generally exhibited lower tyrosine-hydroxylase expression compared to WT mice.

Conclusions:

  • Osteocalcin modulates adrenal gene expression in the catecholamine synthetic pathway.
  • This modulation by OC may explain variations in EtOH consumption under stress.
  • OC plays a role in the interplay between stress, catecholamine production, and EtOH intake.