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3111T/C Clock Gene Polymorphism in Women with Insomnia
N V Semenova1, I M Madaeva2, T I Bairova2
1Research Center of Family Health and Human Reproduction Problems, Irkutsk, Russia. natkor_84@mail.ru.
Abstract:
Comparative analysis of the frequency distributions of genotypes and alleles of 3111T/C Clock gene polymorphism was carried out in climacteric Caucasian women with and without insomnia. Genotype TT is more incident in women with insomnia (55.5% vs. 42.6% in the control). Allele T predominated in the control and study group and its frequency is higher in women with insomnia. The OR for the risk of insomnia realization is 1.78 (95%CI 1.16-2.75). No association between genotypes and complaints of patients with insomnia is detected.
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