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3111T/C Clock Gene Polymorphism in Women with Insomnia
N V Semenova1, I M Madaeva2, T I Bairova2
1Research Center of Family Health and Human Reproduction Problems, Irkutsk, Russia. natkor_84@mail.ru.
Bulletin of Experimental Biology and Medicine
|August 31, 2017
Summary
The Clock gene 3111T/C polymorphism, specifically the TT genotype and T allele, is more frequent in Caucasian women experiencing insomnia. This genetic variation increases the risk of developing insomnia.
Area of Science:
- Genetics
- Sleep Medicine
- Chronobiology
Background:
- Insomnia is a prevalent sleep disorder affecting many women during menopause.
- The Clock gene plays a crucial role in regulating circadian rhythms, which are often disrupted in insomnia.
- Genetic variations in the Clock gene may influence an individual's susceptibility to insomnia.
Purpose of the Study:
- To investigate the association between the 3111T/C polymorphism of the Clock gene and insomnia in Caucasian women.
- To compare the frequency distributions of genotypes and alleles of the Clock gene polymorphism between women with and without insomnia.
Main Methods:
- Genotyping analysis was performed on Caucasian women experiencing climacteric symptoms.
- Case-control study design comparing women with insomnia to a control group without insomnia.
- Statistical analysis included frequency distribution comparison and odds ratio calculation for insomnia risk.
Main Results:
- The TT genotype of the Clock gene 3111T/C polymorphism was found more frequently in women with insomnia (55.5%) compared to controls (42.6%).
- The T allele predominated in both groups, with a higher frequency observed in women with insomnia.
- An odds ratio of 1.78 (95% CI 1.16-2.75) indicated an increased risk of insomnia associated with this polymorphism.
- No significant association was found between Clock gene genotypes and specific insomnia complaints.
Conclusions:
- The 3111T/C Clock gene polymorphism is associated with an increased risk of insomnia in climacteric Caucasian women.
- The TT genotype and T allele of the Clock gene may be genetic risk factors for developing insomnia.
- Further research is warranted to explore the precise mechanisms linking Clock gene variations to sleep disturbances.
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