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Platelet-to-Lymphocyte Ratio: A New Factor for Predicting Systemic Inflammatory Response Syndrome after Percutaneous
Mehmet Cetinkaya1, Ibrahim Buldu2, Omer Kurt3
1Department of Urology, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey. drmemoly@yahoo.com.
Urology Journal
|August 31, 2017
Summary
The preoperative platelet-to-lymphocyte ratio (PLR) can predict systemic inflammatory response syndrome (SIRS) after percutaneous nephrolithotomy (PNL). Patients with a PLR over 114.1 require close monitoring for potential complications.
Area of Science:
- Urology
- Nephrology
- Surgical Oncology
Background:
- Systemic inflammatory response syndrome (SIRS) is a potential complication following percutaneous nephrolithotomy (PNL).
- Identifying predictive biomarkers for SIRS is crucial for patient management after PNL.
Purpose of the Study:
- To identify factors influencing postoperative SIRS development in PNL patients.
- To evaluate the predictive role of preoperative platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) for SIRS after PNL.
Main Methods:
- Retrospective analysis of 192 patients undergoing conventional PNL for renal stones (2013-2015).
- Comparison of demographic, operative, and laboratory data between patients who developed SIRS and those who did not.
- Multivariate logistic regression analysis to determine independent risk factors for SIRS.
Main Results:
- Univariate analysis identified significant differences in preoperative PLR, NLR, operative time, hemoglobin decrease, and other factors between SIRS and non-SIRS groups.
- Multivariate analysis revealed that only preoperative PLR and the number of access sites were independent predictors of SIRS.
- A PLR cutoff of 114.1 predicted SIRS development with 80.4% sensitivity and 60.2% specificity.
Conclusions:
- The preoperative PLR is an effective, inexpensive biomarker for predicting SIRS post-PNL.
- Patients with a preoperative PLR exceeding 114.1 warrant close monitoring due to increased risk of complications.
