Related Experiment Video
Updated: Feb 23, 2026
11:18
Direct Drug Delivery to Kidney via the Renal Artery
Published on: April 17, 2021
8.3K
Enhancing clinical trial development for pediatric kidney diseases
H William Schnaper1, Joseph T Flynn2, Coleman Gross3
1Department of Pediatrics (Kidney Diseases), Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Pediatric Research
|August 31, 2017
Summary
Pediatric clinical trials face challenges due to clinician workload and limited patient numbers. The American Society of Pediatric Nephrology Therapeutics Development Committee (TDC) aims to improve trial development by fostering collaboration among stakeholders in pediatric kidney disease research.
Area of Science:
- Pediatric Nephrology
- Clinical Trial Management
- Healthcare Collaboration
Background:
- Conducting clinical trials in pediatric nephrology is challenging due to high clinical demands on specialists and a limited patient population.
- These constraints hinder the development and execution of essential research studies for children with kidney disease.
Purpose of the Study:
- To establish the American Society of Pediatric Nephrology Therapeutics Development Committee (TDC).
- To identify stakeholders involved in pediatric kidney disease clinical trials.
- To foster effective partnerships for successful clinical trial development and execution.
Main Methods:
- The article discusses the rationale, structure, and function of the TDC.
- It outlines the committee's progress toward its established goals.
- Insights gained from the TDC's experience are presented.
Main Results:
- The TDC was formed to address challenges in pediatric nephrology clinical trials.
- The committee focuses on stakeholder identification and partnership development.
- Progress and insights are being generated to improve trial conduct.
Conclusions:
- The TDC provides a framework for overcoming obstacles in pediatric clinical research.
- Effective collaboration is crucial for advancing pediatric nephrology trials.
- The TDC's model offers valuable lessons for other pediatric subspecialties facing similar research challenges.
Related Concept Videos
01:26Pharmacokinetics in Pediatric Patients: Drug Excretion
303
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
303
01:24Pharmacokinetics in Pediatric Patients: Drug Metabolism
276
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
276
01:11Clinical Trials: Overview
5.1K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.1K
01:16Clinical Trials
10.9K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
10.9K
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
364
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
364
01:23Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
353
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
353