Catalytic macrolactonizations for natural product synthesis.
Yong Li1, Xianglin Yin, Mingji Dai
1Department of Chemistry, Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, USA. mjdai@purdue.edu.
Natural Product Reports
|August 31, 2017
Summary
Recent catalytic methods enable macrolactone synthesis without seco acids, advancing natural product synthesis. These strategies improve efficiency and economy in creating complex molecules.
Area of Science:
- Organic Chemistry
- Synthetic Chemistry
Background:
- Macrolactones are crucial structural units in pharmaceuticals and natural products.
- Traditional synthesis relies on stoichiometric reagents and seco acids, often lacking efficiency.
Purpose of the Study:
- To review recent advancements in catalytic macrolactonization methods.
- To highlight strategies that bypass the need for seco acids.
- To showcase applications in total synthesis of natural products.
Main Methods:
- Catalytic C-H macrolactonization.
- Enantioselective Rh-catalyzed redox-neutral allene-acid cyclization.
- Catalytic carbonylative macrolactonization.
- NHC-catalyzed oxidative macrolactonization.
Main Results:
- Development of efficient catalytic macrolactonization techniques.
- Successful application of these methods in natural product synthesis.
- Demonstration of strategies avoiding traditional seco acid precursors.
Conclusions:
- Catalytic macrolactonization offers efficient and economical routes to complex macrolactones.
- These methods are valuable tools for natural product total synthesis.
- Future research likely to focus on further expanding catalytic strategies.
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