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Related Concept Videos

Whole Body Regeneration01:33

Whole Body Regeneration

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Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
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Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
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Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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Gene Conversion02:08

Gene Conversion

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Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
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Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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In-vitro Mutagenesis01:16

In-vitro Mutagenesis

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To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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Related Experiment Video

Updated: Feb 23, 2026

Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting
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Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting

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Regeneration Genetics.

Chen-Hui Chen1, Kenneth D Poss2,3

  • 1Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan;

Annual Review of Genetics
|August 31, 2017
PubMed
Summary
This summary is machine-generated.

Genetic approaches are revolutionizing the study of animal regeneration. Researchers are uncovering the cellular and molecular mechanisms that drive tissue repair, paving the way for regenerative medicine advancements.

Keywords:
blastemageneticsimagingregenerationsalamanderszebrafish

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Pharmacological and Functional Genetic Assays to Manipulate Regeneration of the Planarian Dugesia japonica
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Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration
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Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

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Pharmacological and Functional Genetic Assays to Manipulate Regeneration of the Planarian Dugesia japonica
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Area of Science:

  • Regenerative Biology
  • Genetics
  • Developmental Biology

Background:

  • Animal regeneration offers transformative potential for regenerative medicine.
  • Understanding the fundamental mechanisms of tissue repair is crucial.

Purpose of the Study:

  • To provide an overview of genetic approaches used to study regeneration.
  • To highlight recent advances in defining cellular sources, molecular triggers, and early events in regeneration.

Main Methods:

  • Review of genetic strategies applied to regeneration research.
  • Focus on studies investigating vertebrates across different tissues and species.

Main Results:

  • Advances in identifying cellular origins and behaviors during regeneration.
  • Elucidation of molecular regulators (triggers and brakes) controlling regenerative processes.
  • Characterization of early molecular events that govern regeneration.

Conclusions:

  • Genetic approaches are powerful tools for dissecting complex regeneration mechanisms.
  • Continued research in this area holds significant promise for future regenerative therapies.