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Related Experiment Videos

Glucagon's chronotropic action is calcium dependent.

B Chernow, G P Zaloga, D Malcolm

    The Journal of Pharmacology and Experimental Therapeutics
    |June 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

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    Glucagon

    Area of Science:

    • Cardiovascular Physiology
    • Endocrinology

    Background:

    • Anesthetics and cardiovascular drugs can affect cellular calcium (Ca) kinetics.
    • Glucagon's heart rate effects are linked to Ca channels, not beta-adrenergic receptors.

    Purpose of the Study:

    • To investigate if ionized calcium concentrations influence glucagon's ability to increase heart rate in rats.

    Main Methods:

    • Rats were made hypercalcemic (calcium chloride) or hypocalcemic (EDTA).
    • Ionized calcium levels were measured.
    • Glucagon's tachycardic effects were assessed under varying calcium conditions.

    Main Results:

    • Normocalcemic rats had a mean ionized Ca of 4.73 mg/dl.
    • Hypercalcemia (up to 15.2 mg/dl) and hypocalcemia (down to 2.13 mg/dl) significantly blunted glucagon's heart rate increase.

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  • Glucagon's chronotropic action was reduced by 51% in severe hypocalcemia and 44% in severe hypercalcemia.

    • Conclusions:

    • Glucagon's heart rate-increasing effect is dependent on physiological calcium levels.
    • Both high and low calcium levels diminish glucagon's tachycardic action.