Genetic insights into mammalian heart regeneration
Related Experiment Video
Updated: Aug 31, 2026

06:08
Apical Resection Mouse Model to Study Early Mammalian Heart Regeneration
Published on: January 23, 2016
11.9K
Ana Vujic1, Vinícius Bassaneze1, Richard T Lee1
1Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA.
Nature Genetics
|August 31, 2017
Abstract:
Genetic and functional analyses of 120 mouse strains have identified a heart regeneration candidate gene that modulates the contractile sarcomeric apparatus. This gene, Tnni3k, controls the frequency of the mononuclear, diploid cardiomyocyte population, which affects cardiomyocyte proliferative potential after injury.

