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[Heredity in clinical cancer].
Gan No Rinsho. Japan Journal of Cancer Clinics
|April 1, 1987
Summary
Cancer susceptibility can run in families due to genetic factors. This review discusses heritable cancers and new methods for identifying cancer predisposition.
Area of Science:
- Genetics
- Oncology
- Epidemiology
Context:
- Familial cancer clustering presents challenges in understanding individual cancer susceptibility.
- Clustering may arise from shared environmental factors or discrete genetic influences (recessive or dominant inheritance).
Purpose:
- To review and discuss known heritable cancers.
- To introduce recent laboratory advancements for identifying cancer predisposition.
- To summarize genetic epidemiological analyses of individual differences in cancer risk.
Summary:
- This review explores the genetic basis of familial cancer clustering, differentiating between environmental and inherited causes.
- It details Mendelian inheritance patterns (recessive and dominant) in hereditary cancers.
- The article highlights advancements in molecular biology, including fragile site analysis and restriction fragment length polymorphism, for cancer predisposition studies.
- Genetic epidemiology methods for assessing individual susceptibility are also summarized.
Impact:
- Provides a comprehensive overview of hereditary cancer syndromes.
- Highlights the importance of genetic factors in cancer etiology.
- Informs research into novel diagnostic tools and personalized cancer prevention strategies.