Related Experiment Video
Updated: Feb 23, 2026
Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
Published on: October 31, 2025
Transfusion-related acute lung injury following PDA ligation in a preterm neonate
R G LaGrandeur1, M Tran2, C Merchant1
1Division of Neonatology, Department of Pediatrics, University of California Irvine Medical Center, Orange, CA, USA.
Abstract:
Transfusion-related acute lung injury (TRALI) is a life-threatening complication of blood product transfusion characterized by sudden onset hypoxemic respiratory failure with bilateral lung infiltrates and non-cardiogenic pulmonary edema developing within 6 hours of transfusion. It is believed to be under-recognized, particularly among preterm neonates in whom co-existing developmental lung disease adds diagnostic complexity. Here we report the case of a preterm neonate who developed TRALI during a blood transfusion following PDA ligation.
