Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Generalised osteoarthritis: an evolutionary problem?

C W Hutton

    Lancet (London, England)
    |June 27, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Generalised osteoarthritis (OA) affects specific joints due to rapid evolutionary changes. Joints with increased loading from new functions are more susceptible to early OA development.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A rapidly destructive amyloid arthropathy associated with myeloma.

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2008
    Same author

    Premature osteoarthritis of the knee associated with cartilage hypertrophy and phalangeal dysgenesis.

    Skeletal radiology·2005
    Same author

    Magnetic resonance imaging of rheumatoid arthritis in metacarpophalangeal joints.

    Skeletal radiology·2000
    Same author

    Mannosidosis: an unusual cause of a deforming arthropathy.

    Skeletal radiology·2000
    Same author

    Osteoarthritis and magnetic resonance imaging: potential and problems.

    Annals of the rheumatic diseases·1995
    Same author

    Avascular necrosis of bone following intensified steroid therapy for acute lymphoblastic leukaemia and high-grade malignant lymphoma.

    British journal of haematology·1994

    Area of Science:

    • Evolutionary biology
    • Rheumatology
    • Orthopedics

    Background:

    • Polyarticular osteoarthritis (OA) exhibits a distinct pattern of joint involvement.
    • Certain joints like the first metatarsophalangeal joint are frequently affected, while others, such as the shoulder, are rarely involved.
    • This pattern suggests a potential subset of OA termed generalised OA.

    Purpose of the Study:

    • To propose a hypothesis explaining the joint involvement pattern in generalised OA.
    • To link joint susceptibility in OA to evolutionary changes in human joint function.

    Main Methods:

    • Analysis of joint function changes during recent human evolutionary development.
    • Correlation of evolutionary joint loading changes with observed OA prevalence patterns.

    Related Experiment Videos

    Main Results:

    • Joints most commonly affected by generalised OA have undergone rapid evolutionary adaptation to increased loading.
    • These highly loaded joints are relatively underdesigned with limited functional reserve, leading to early failure.
    • Rarely affected joints show evolutionary adaptation to reduced loading, possessing overdesign and large functional reserves, thus failing late.

    Conclusions:

    • The pattern of joint involvement in generalised OA can be explained by evolutionary adaptations to changing functional demands.
    • Recent rapid evolutionary increases in joint loading contribute to susceptibility and early failure in specific joints.
    • Conversely, evolutionary decreases in joint loading protect other joints from OA.