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Related Concept Videos

Vaccinations01:51

Vaccinations

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Overview
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Cancer Vaccines01:30

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

249
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

289
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
289

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Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
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Vaccines for Older Adults.

Chad Worz, Caren McHenry Martin, Catherine Travis

    The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists
    |September 1, 2017
    PubMed
    Summary

    Older adults face risks from influenza, pneumonia, herpes zoster, and pertussis. Pharmacists are key to ensuring seniors receive timely, recommended vaccinations to prevent these diseases.

    Area of Science:

    • Gerontology
    • Infectious Diseases
    • Public Health

    Background:

    • Vaccine-preventable diseases pose significant health risks to older adults in the U.S.
    • These illnesses can lead to increased morbidity, mortality, and healthcare costs in the elderly population.

    Purpose of the Study:

    • To highlight the threat of influenza, pneumonia, herpes zoster, and pertussis to older adults.
    • To emphasize the critical role of healthcare professionals, particularly pharmacists, in vaccine administration for this demographic.

    Main Methods:

    • Review of existing literature on vaccine-preventable diseases in older adults.
    • Analysis of the impact of these diseases on morbidity, mortality, and economic burden.
    • Examination of the role of pharmacists in promoting and administering adult immunizations.

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    Main Results:

    • Influenza, pneumonia, herpes zoster, and pertussis are major threats to the health of U.S. seniors.
    • The economic and health consequences of these diseases are substantial for the elderly.
    • Pharmacists are integral to ensuring adherence to recommended vaccination schedules for older adults.

    Conclusions:

    • Vaccination is crucial for protecting older adults from serious infectious diseases.
    • Healthcare providers must prioritize and facilitate the vaccination of elderly patients.
    • Pharmacists are essential partners in public health initiatives aimed at increasing adult immunization rates.