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Updated: Feb 23, 2026

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FoxM1: Repurposing an oncogene as a biomarker.

Deeptashree Nandi1, Pradeep Singh Cheema1, Neha Jaiswal1

  • 1Department of Biochemistry, University of Delhi South Campus, New Delhi, 110021, India.

Seminars in Cancer Biology
|September 1, 2017
PubMed
Summary

The transcription factor FoxM1 drives cancer initiation and progression, offering resistance to therapies. Targeting FoxM1 shows promise as a novel biomarker for cancer diagnosis and treatment.

Keywords:
BiomarkerCancerDiagnosisFoxM1OncogenePrognosisTherapy

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer research has advanced significantly, improving diagnosis and screening through gene expression profiling.
  • Novel biomarkers are crucial for early cancer detection and personalized treatment strategies.

Purpose of the Study:

  • To review the literature on the oncogenic functions of the transcription factor FoxM1.
  • To highlight FoxM1's potential as a predictive, prognostic, and therapeutic marker in various cancers.

Main Methods:

  • Comprehensive literature review of studies investigating FoxM1 in cancer.
  • Analysis of accumulated data on FoxM1's role in cancer hallmarks.

Main Results:

  • FoxM1 is implicated in cancer initiation, development, and progression.
  • FoxM1 promotes cell proliferation and confers resistance to anti-cancer therapies.
  • Emerging evidence supports FoxM1's utility as a biomarker.

Conclusions:

  • FoxM1's multifaceted oncogenic functions present it as a promising biomarker.
  • Harnessing FoxM1's features can enhance cancer diagnosis and treatment strategies.