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Updated: Feb 23, 2026

Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
Diseases AND or IN frailty, an important conceptual difference.
Miguel Germán Borda1, Daniela Patino-Hernandez2
1Semillero de Neurociencias y Envejecimiento, Aging Institute and Faculty of Medicine, Pontificia Universidad Javeriana, Bogotá, Colombia; Geriatrics Unit, Hospital Universitario San Ignacio and Pontificia Universidad Javeriana, Bogotá, Colombia.
Frailty, a state of increased vulnerability, is often overlooked in medicine. Recognizing frailty as integral to disease, not separate, requires a person-centered approach, especially in geriatric care.
Area of Science:
- Gerontology
- Internal Medicine
- Clinical Geriatrics
Background:
- Frailty is a recognized clinical state associated with increased vulnerability.
- It serves as an important outcome marker across various medical conditions.
- Current medical recognition of frailty is insufficient, often treating it as secondary to disease.
Purpose of the Study:
- To highlight the importance of frailty as a distinct clinical state.
- To advocate for a paradigm shift in medical understanding and management of frailty.
- To emphasize the role of geriatricians in managing frail individuals.
Main Methods:
- Conceptual analysis of frailty within medical literature.
- Review of the role of geriatricians in multidisciplinary care teams.
- Discussion of the limitations of traditional illness-focused medical approaches.
Main Results:
- Frailty is frequently an intrinsic component or outcome of diseases, not merely an added condition.
- A significant gap exists in the medical field's recognition and integration of frailty.
- Geriatricians play a crucial role in addressing the complex needs of frail older adults.
Conclusions:
- Frailty requires a fundamental shift in medical perspective, moving beyond a disease-centric model.
- A multidimensional, person-centered approach is essential for effectively managing frailty.
- Integrating frailty assessment and management is critical for improving geriatric care outcomes.
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