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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

992
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
992
Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

47
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
47
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

41
Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
41
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

64
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
64
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

54
Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
54
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

883
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
883

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Related Experiment Video

Updated: Feb 23, 2026

Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions
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Subcutaneous drug delivery: An evolving enterprise.

Graham B Jones1, David S Collins2, Michael W Harrison2

  • 1Clinical and Translational Science Institute, Tufts University Medical Center, Boston, MA 02111, USA. graham.jones@tufts.edu.

Science Translational Medicine
|September 1, 2017
PubMed
Summary

Recent innovations in subcutaneous drug delivery and device design are revolutionizing the biopharmaceutical industry. These advancements enhance therapeutic efficacy and significantly improve patient outcomes and care.

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Area of Science:

  • Biopharmaceutical sector
  • Drug delivery systems
  • Medical device engineering

Background:

  • Subcutaneous drug delivery offers an alternative to traditional administration routes.
  • Device design is critical for effective and safe drug administration.
  • Patient adherence and convenience are key considerations in drug delivery.

Purpose of the Study:

  • To highlight recent advancements in subcutaneous drug delivery.
  • To discuss innovations in device design for biopharmaceuticals.
  • To explore the impact of these developments on patient care.

Main Methods:

  • Review of recent scientific literature and industry reports.
  • Analysis of emerging trends in drug delivery technologies.
  • Case studies of innovative subcutaneous devices.

Main Results:

  • Significant progress in developing novel subcutaneous injection devices.
  • Improved drug formulations for enhanced subcutaneous absorption.
  • Demonstrated potential for increased therapeutic effectiveness.

Conclusions:

  • Subcutaneous drug delivery innovations are transforming biopharmaceutical development.
  • Advanced devices are improving patient experience and treatment adherence.
  • The field is poised for continued growth and patient benefit.