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NF-κB-dependent Signaling Pathway

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
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Related Experiment Video

Updated: Feb 23, 2026

Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging

Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging

Published on: July 1, 2021

Enhancing brown fat with NFIA.

Suzanne N Shapira¹, Patrick Seale¹

¹Institute for Diabetes, Obesity, and Metabolism, Department of Cell and Developmental Biology, Smilow Center for Translational Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Nature Cell Biology

|September 1, 2017

Summary

This summary is machine-generated.

Nuclear factor I-A (NFIA) is a key transcription factor that activates the brown adipose tissue genetic program. NFIA binds to specific DNA elements to control the metabolic organ

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Last Updated: Feb 23, 2026

Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging

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Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue

Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue

Published on: October 7, 2014

Area of Science:

Metabolic research
Adipose tissue biology
Gene regulation

Background:

Brown adipose tissue (BAT) is crucial for thermogenesis, oxidizing fatty acids and glucose.
Understanding the molecular mechanisms controlling BAT function is vital for metabolic health.

Purpose of the Study:

To identify key transcription factors regulating the brown fat genetic program.
To elucidate the role of nuclear factor I-A (NFIA) in adipose tissue differentiation and function.

Main Methods:

Epigenomic analyses across multiple adipose tissue depots.
Chromatin immunoprecipitation sequencing (ChIP-seq) to identify NFIA binding sites.
Integration of epigenomic data with gene expression profiles.

Main Results:

NFIA was identified as a critical transcription factor in brown adipose tissue.
NFIA directly binds to lineage-specific cis-regulatory elements in BAT.
NFIA drives the expression of key genes within the brown fat genetic program.

Conclusions:

NFIA plays a central role in establishing and maintaining the brown adipose tissue identity.
Targeting NFIA may offer therapeutic strategies for metabolic disorders associated with impaired thermogenesis.