Related Experiment Video
Updated: Feb 23, 2026

Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
DNA sensing in senescence
Marina Ruiz de Galarreta1, Amaia Lujambio1,2
1Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York 10029, USA and at the Liver Cancer Program, Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York 10029, USA.
Abstract:
Cellular senescence, a cell-autonomous growth arrest program, also executes pleiotropic non-cell-autonomous activities through the senescence-associated secretory phenotype (SASP). The innate cGAS-STING DNA-sensing pathway is now shown to regulate senescence by recognizing cytosolic DNA and inducing SASP factors, uncovering an unexpected link between these two previously unrelated pathways.
More Related Videos
08:18Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
13:59A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
Published on: August 12, 2018
Related Concept Videos
Replicative Cell Senescence
Overview of DNA Repair
Chemically...
DNA Damage can Stall the Cell Cycle
DNA Damage Can Stall the Cell Cycle
Nucleotide Excision Repair
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...