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Is Helicobacter pylori Infection a Risk Factor for Prostatitis? A Case-Control Study in a Referring Tertiary Care
Alireza Abdollahi1, Masoud Etemadian2, Saeed Shoar1,3
1Dept. of Pathology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Insights
Helicobacter pylori infection is linked to chronic prostatitis. Elevated levels of anti-H. pylori IgG and IgA antibodies were observed in patients with chronic prostatitis, suggesting a potential treatment target.
Area of Science:
- Urology
- Infectious Diseases
- Immunology
Background:
- The etiology of chronic prostatitis remains unclear, hindering optimal treatment strategies.
- This study investigates the potential association between Helicobacter pylori infection and chronic prostatitis.
Purpose of the Study:
- To determine if Helicobacter pylori infection is associated with chronic prostatitis.
- To compare serum levels of anti-H. pylori antibodies between patients with chronic prostatitis and healthy controls.
Main Methods:
- A prospective case-control study was conducted with 59.5 ± 3.08 yr old patients diagnosed with chronic prostatitis and healthy controls.
- Serum levels of anti-Helicobacter pylori IgG and IgA were measured.
- Data were analyzed using SPSS, with P<0.05 considered statistically significant.
Main Results:
- Patients with chronic prostatitis showed significantly higher mean levels of anti-H. pylori IgG (20.94 ± 16.98 U/ml) and IgA (18.63 ± 15.65 U/ml) compared to controls (9.36 ± 7.45 U/ml and 6.25 ± 7.29 U/ml, respectively).
- No significant difference in age was observed between the case and control groups (P>0.05).
Conclusions:
- Chronic prostatitis is associated with Helicobacter pylori infection.
- Elevated serum IgG and IgA antibodies against H. pylori indicate a potential role for this infection in the pathogenesis of chronic prostatitis.
- Targeting H. pylori infection may offer a therapeutic approach for managing chronic prostatitis.
Background:
The optimal treatment is not possible yet for chronic prostatitis due to the unknown etiology of the diseases. We aimed to investigate the association of Helicobacter pylori infection with chronic prostatitis.
Methods:
In this prospective case-control study that conducted in Imam Hospital Complex affiliated to Tehran University of Medical Sciences in Tehran, Iran from 2014 to 2015, patients with diagnosis of chronic prostatitis according to the criteria of National Institute of Health (NIH) were enrolled. Control group constituted of consecutive healthy patients. Blood samples were obtained for each patient and control and evaluated for serum levels of anti H. pylori IgG, A. Data analysis was carried out using SPSS, version 18. Values of P<0.05 were considered statistically significant.
Results:
Mean ± SD age of patients was 59.5 ± 3.08 yr in the case group and 56.88 ± 3.20 yr in the control group with no significant difference (P>0.05). Mean ± SD levels of anti H. pylori IgG and IgA in the control group were 9.36 ± 7.45 U/ml and 6.25 ± 7.29 U/ml, respectively compared with 20.94 ± 16.98 U/ml and 18.63 ± 15.65 U/ml in the case group, respectively both of which revealed statistically significant (P<0.05).
Conclusion:
Chronic prostatitis is associated with H. pylori infection. Both anti H. pylori IgG and IgA are increased in patients with chronic prostatitis. Therefore, treatment of HP infection could be effective in the prostatitis cure.
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