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Updated: Feb 23, 2026

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles

Published on: October 19, 2015

Development, evaluation and optimization of superparamagnetite nanoparticles prepared by co-precipitation method.

Hashem Montaseri¹, Shohreh Alipour¹, Molood Alsadat Vakilinezhad¹

¹Quality control Department, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.

Research in Pharmaceutical Sciences

|September 1, 2017

Summary

Magnetically soft magnetite nanoparticles (Fe3O4) show promise for theranostics, offering high magnetization and low toxicity. Surface coatings enhance their stability and suitability for medical applications.

Keywords:

Citric acid MCF-7 Magnetic nanoparticles Oleic acid SK-Br-3

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Published on: June 16, 2020

Area of Science:

Materials Science
Nanotechnology
Biomedical Engineering

Background:

Magnetic nanoparticles (MNPs) are crucial for theranostics, requiring high magnetization, precise size, and stability.
Magnetite (Fe3O4) nanoparticles offer biocompatibility but face challenges with instability and oxidation.
Co-precipitation is a common synthesis method, but factors influencing particle formation need detailed study.

Purpose of the Study:

To investigate the synthesis and characterization of magnetite nanoparticles (MNPs) for theranostic applications.
To evaluate the effect of surface coatings (oleic acid and citric acid) on MNP properties.
To assess the biocompatibility and magnetic properties of the synthesized MNPs.

Main Methods:

Synthesis of magnetite nanoparticles via co-precipitation.
Surface functionalization using oleic acid (OMNPs) and citric acid (CMNPs).
Characterization using transmission electron microscopy (TEM), magnetic measurements, and cytotoxicity assays.

Main Results:

Synthesized MNPs exhibited sizes of 15 nm (OMNPs) and 13 nm (CMNPs) with high magnetic saturation (72 and 68 emu/g).
Both OMNPs and CMNPs demonstrated non-toxicity to SK-Br-3 and MCF-7 cells at concentrations below 2.5 μg/mL.
Surface coatings improved particle stability and suitability for medical applications.

Conclusions:

Coated magnetite nanoparticles possess suitable magnetic properties and biocompatibility for theranostic applications.
The study demonstrates the potential of MNPs for targeted drug delivery and imaging.
Further research can optimize MNP synthesis for enhanced therapeutic efficacy.