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Updated: Feb 23, 2026

Separation of Mouse Embryonic Facial Ectoderm and Mesenchyme

Separation of Mouse Embryonic Facial Ectoderm and Mesenchyme

Published on: April 12, 2013

Gene expression profile data for mouse facial development.

Sonia M Leach¹, Weiguo Feng^2,3, Trevor Williams^2,3

¹Department of Biomedical Research, Center for Genes, Environment and Health, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA.

|September 1, 2017

Summary

This summary is machine-generated.

This study details gene expression profiles during mouse embryonic facial development. The data aids researchers in understanding gene roles in craniofacial development and birth defects.

Keywords:

Ectodermal Embryonic mouse face Expression profiles Functional genomics Mesenchymal Transcriptome

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Last Updated: Feb 23, 2026

Separation of Mouse Embryonic Facial Ectoderm and Mesenchyme

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Published on: April 12, 2013

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Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

Published on: February 22, 2016

Area of Science:

Developmental Biology
Genomics
Bioinformatics

Background:

Embryonic mammalian craniofacial development is complex, involving facial prominence growth and fusion.
Gene dysregulation can cause severe craniofacial birth defects like orofacial clefting.

Purpose of the Study:

To build individual gene expression profiles from existing datasets for mouse facial development.
To illustrate gene expression timing in whole facial prominences and separated tissue layers (ectoderm and mesenchyme).

Main Methods:

Utilized RNA expression data from microarrays of dissected embryonic mouse facial prominences (E10.5-E12.5).
Separated facial prominences into ectoderm and mesenchyme layers for layer-specific analysis.
Developed indexed, clickable gene expression profiles with graphical representations.

Main Results:

Generated gene expression profiles detailing expression levels over time, across tissue types, and within specific prominences.
Profiles show expression trajectories in ectoderm, mesenchyme, and intact facial prominences.
Data facilitates rapid assessment of gene expression in embryonic mouse facial development.

Conclusions:

The generated data profiles provide a valuable resource for craniofacial developmental biology research.
Enables rapid assessment of gene expression dynamics crucial for understanding normal development and disease.
Facilitates investigation into the genetic basis of craniofacial anomalies.