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Related Experiment Video

Updated: Feb 23, 2026

Evaluation of Blood Lactate and Plasma Insulin During High-intensity Exercise by Antecubital Vein Catheterization
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Computed exercise plasma lactate concentrations: A conversion formula.

Lia Bally1, Thomas Zueger1, Christoph Stettler1

  • 1Division of Endocrinology, Diabetes & Clinical Nutrition, Inselspital, University Hospital Bern, Switzerland.

Practical Laboratory Medicine
|September 1, 2017
PubMed
Summary
This summary is machine-generated.

Whole blood lactate can be reliably converted to plasma lactate for field use. This formula provides accurate estimates comparable to laboratory measurements, aiding sports medicine applications.

Keywords:
Enzyme electrodesHematocritLactatePlasma vs whole-bloodSample treatment

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Area of Science:

  • Biomedical Science
  • Sports Medicine
  • Clinical Chemistry

Background:

  • Blood lactate is a key marker for skeletal muscle metabolism in sports medicine.
  • Plasma lactate offers a more accurate reflection of muscle lactate than whole blood lactate.
  • Field-based whole blood lactate measurements are convenient but require conversion for plasma accuracy.

Purpose of the Study:

  • To develop a formula for converting whole blood lactate to plasma lactate for practical field use.
  • To validate the accuracy of the computed plasma lactate values against a standard laboratory method.

Main Methods:

  • Collected 91 venous blood samples from 6 individuals with type 1 diabetes under resting and exercise conditions.
  • Measured whole blood and plasma lactate using the YSI 2300 analyzer.
  • Applied a linear model to derive a conversion formula and assessed validity using Passing-Bablok regression.

Main Results:

  • Established a formula converting whole blood lactate to plasma lactate (slope 1.66, intercept 0.12) for samples with normal hematocrit.
  • Computed plasma lactate values showed strong agreement with laboratory standard methods (slope 1.03, intercept -0.11).

Conclusions:

  • Whole blood lactate measurements can be reliably converted to plasma lactate values using the derived formula.
  • The conversion method provides plasma lactate estimates consistent with laboratory findings, suitable for field applications.