Distribution of HBV genotypes in Poland

Area of Science:

• Hepatology
• Virology
• Epidemiology

Background:

• Hepatitis B virus (HBV) infection remains a significant global health concern.
• Understanding the distribution of HBV genotypes is crucial for effective treatment and prevention strategies.
• Previous epidemiological data on HBV genotypes in Poland were limited.

Purpose of the Study:

• To determine the current distribution of HBV genotypes in various regions of Poland.
• To identify regional variations in HBV genotype prevalence across the country.

Main Methods:

• A study involving 270 treatment-naïve, HBV-infected individuals from 7 centers in Poland.
• HBV genotyping was performed using the INNO-LiPA HBV Genotyping assay on 243 participants.

Main Results:

• Hepatitis B virus (HBV) genotype A was the most predominant (approximately 66.7%), followed by genotype D (20%), H (5%), and mixed A+D (5%).
• Significant regional differences were observed: genotype D prevalence was higher (around 30%) in eastern and south-western Poland, while genotype A exceeded 80% in central Poland.

Conclusions:

• This study presents the first and largest epidemiological analysis of HBV genotype distribution in Poland.
• The findings highlight significant regional variations in HBV genotypes, with genotype A being dominant overall but with notable regional shifts towards genotype D in specific areas.