Liver involvement in children with collagen vascular diseases

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Joanna Pawłowska1, Magdalena Naorniakowska1, Anna Liber2

  • 1Department of Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children's Memorial Health Institute (CMHI), Warsaw.

Clinical and Experimental Hepatology
|September 1, 2017
PubMed

Insights

Pediatric liver injury, including enlarged liver and spleen, is common in children with collagen vascular diseases. Causes include drug toxicity, infections, diabetes, and autoimmune hepatitis overlap.

Area of Science:

  • Pediatric Rheumatology
  • Hepatology
  • Internal Medicine

Background:

  • Collagen vascular diseases frequently manifest with hepatic complications in pediatric patients.
  • Liver abnormalities like hepatomegaly and splenomegaly are observed with varying biochemical changes.

Purpose of the Study:

  • To summarize the common causes and manifestations of liver injury in children diagnosed with collagen vascular diseases.

Main Methods:

  • Review of clinical presentations and etiological factors associated with liver abnormalities in pediatric collagen vascular disease patients.

Main Results:

  • Hepatomegaly and splenomegaly are prevalent findings.
  • Biochemical abnormalities of the liver are common.
  • Secondary causes of liver injury are frequent, including drug toxicity, infections, and autoimmune hepatitis overlap.

Conclusions:

  • Liver injury is a significant clinical issue in pediatric collagen vascular diseases.
  • Identifying secondary causes is crucial for appropriate management.
  • Multidisciplinary approaches are often necessary for comprehensive care.

Keywords:
Kawasaki diseasechildrenjuvenile rheumatoid arthritisliver diseasessystemic lupus erythematosus

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