Related Experiment Video
Updated: Feb 23, 2026
03:47
A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients
Published on: October 25, 2024
697
Tubercular Intestinal Strictures Show a Poor Response to Anti-Tuberculous Therapy
Piyush Aggarwal1, Saurabh Kedia1, Raju Sharma2
1Department of Gastroenterology, All India Institute of Medical Sciences, Room No 3111, Third Floor, Teaching Block, New Delhi, 110070, India.
Digestive Diseases and Sciences
|September 1, 2017
Summary
Only 23.6% of intestinal tuberculosis strictures resolved after anti-tuberculous therapy. Stricture location impacts resolution, with colonic strictures showing the lowest rates. Many patients still experience symptoms post-treatment.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Pulmonology
Background:
- Intestinal tuberculosis (ITB) can lead to strictures, a complication with limited data on resolution after treatment.
- Existing literature on stricture resolution following anti-tuberculous therapy (ATT) is sparse and inconclusive.
Purpose of the Study:
- To determine the frequency of intestinal stricture resolution in ITB patients after completing ATT.
- To identify predictors associated with stricture resolution in ITB.
Main Methods:
- An ambispective cohort study included 106 ITB patients with strictures receiving at least 6 months of ATT.
- Stricture resolution was evaluated post-ATT using endoscopic and radiological assessments.
- Data were collected from January 2004 to December 2015.
Main Results:
- Stricture resolution was observed in only 23.6% (25/106) of ITB patients, despite mucosal healing in all.
- Colonic strictures had the lowest resolution rate (5.4%), followed by proximal small intestinal (20%) and distal ileal/ileocecal (36.5%).
- Symptoms related to strictures persisted in over half of the patients post-ATT.
Conclusions:
- Intestinal stricture resolution following ATT is infrequent in ITB patients.
- Disease location is a significant factor influencing stricture resolution.
- A majority of ITB patients with strictures continue to experience related symptoms even after therapy completion.
Related Concept Videos
01:28Pulmonary Tuberculosis V
669
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
669
01:30Esophageal Strictures-I: Introduction
984
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
984
01:21Inflammatory Bowel Disease V: Surgical Management
755
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
755
01:26Esophageal Strictures-II: Clinical Features and Management
738
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
738
01:17Chronic Bowel Disorders: Introduction
839
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
839
01:29Pulmonary Tuberculosis I
1.1K
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.1K