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Published on: March 25, 2022
Helicobacter bilis-Associated Suppurative Cholangitis in a Patient with X-Linked Agammaglobulinemia
Nicolas Degand1,2, Justine Dautremer3, Benoît Pilmis4
1Université Paris Descartes - Sorbonne Paris Cité, Laboratoire de Microbiologie, Hôpital Necker-Enfants Malades, Assistance Publique - Hôpitaux de Paris, Paris, France. degand.n@chu-nice.fr.
Abstract:
ᅟ: Helicobacter bilis is a commensal bacterium causing chronic hepatitis and colitis in mice. In humans, enterohepatic Helicobacter spp. are associated with chronic hepatobiliary diseases.
Purpose:
We aimed at understanding the microbial etiology in a patient with X-linked agammaglobulinemia presenting with suppurative cholangitis.
Methods:
16S rDNA PCR directly performed on a liver biopsy retrieved DNA of H. bilis.
Results:
Clinical outcome resulted in the normalization of clinical and biological parameters under antibiotic treatment by a combination of ceftriaxone, metronidazole, and doxycyclin followed by a 2-week treatment with moxifloxacin and a 2-month treatment with azithromycin.
Conclusion:
In conclusion, these data suggest a specific clinical and microbiological approach in patients with humoral deficiency in order to detect H. bilis hepatobiliary diseases.
