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Can FSH influence longevity?

Andrzej Bartke1

  • 1Department of Internal Medicine, SIU School of Medicine, 801 N. Rutledge, P.O. Box 19628, Springfield, IL, 62704-9628, USA.

Aging Cell
|September 1, 2017
PubMed
Summary
This summary is machine-generated.

Follicle-stimulating hormone (FSH) may influence aging and longevity by regulating energy balance. Reduced FSH levels correlate with enhanced thermogenesis, suggesting a role in lifespan regulation.

Keywords:
Aginglife spanlongevitylongevity regulationmicemolecular biology of aging

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Area of Science:

  • Endocrinology
  • Aging Research
  • Metabolism

Background:

  • Recent studies indicate extragonadal functions of follicle-stimulating hormone (FSH), including regulation of adipose tissue and thermogenesis.
  • Evidence suggests reduced FSH levels and increased thermogenesis in long-lived mice with growth hormone (GH) deficiency or GH resistance.

Purpose of the Study:

  • To investigate the potential role of FSH in the control of aging and longevity.
  • To explore the relationship between FSH secretion, energy metabolism, and lifespan.

Main Methods:

  • Analysis of FSH levels in relation to thermogenesis and lifespan in mouse models.
  • Review of existing literature on extragonadal FSH actions and aging.

Main Results:

  • Reduced FSH levels were observed in long-lived GH-deficient and GH-resistant mice.
  • These mice exhibited enhanced thermogenesis, suggesting a link between FSH, metabolism, and longevity.

Conclusions:

  • FSH may play a role in regulating aging and longevity.
  • Alterations in FSH secretion could be a mechanism underlying the trade-off between reproduction and aging.