Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renal micropolyarteritis: a treatable condition.

R A Coward, N A Hamdy, J S Shortland

    Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of active infection on cytochrome P450-mediated metabolism of cyclosporine in renal transplant patients.

    Transplant infectious disease : an official journal of the Transplantation Society·2015
    Same author

    Influence of comorbidities on transplant outcomes in patients aged 50 years or more after myeloablative conditioning incorporating fludarabine, BU and ATG.

    Bone marrow transplantation·2010
    Same author

    Fibrinopeptide A, Thromboxane B(2) and Beta-thromboglobulin Levels in Bleeding Time Blood in Uraemia.

    Platelets·2010
    Same author

    Development of pilonidal sinus in an old exit site four years after removal of the Tenckhoff catheter.

    Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis·2010
    Same author

    A feasibility, pharmacokinetic and frequency-escalation trial of intraperitoneal chemotherapy in high risk gastrointestinal tract cancer.

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2007
    Same author

    Prednisolone and azathioprine in membranous nephropathy: a 10-year follow-up study.

    Clinical nephrology·2006

    This study on renal vasculitis found that prognosis is better than previously reported, with significant renal recovery possible even in elderly patients. Immunosuppression did not show a clear benefit for kidney function recovery.

    Area of Science:

    • Nephrology
    • Rheumatology
    • Immunology

    Background:

    • Vasculitis affecting the kidneys, such as microscopic polyarteritis nodosa (microPAN) and Wegener's granulomatosis, can lead to severe renal impairment.
    • Previous studies have indicated a poor prognosis for patients with renal vasculitis.

    Purpose of the Study:

    • To evaluate the long-term outcomes and prognostic factors in patients with renal vasculitis.
    • To assess the effectiveness of different immunosuppressive regimens on renal recovery.

    Main Methods:

    • A 10-year retrospective study involving 36 patients with renal microPAN or Wegener's granulomatosis.
    • Analysis of renal function, need for dialysis, treatment regimens, and survival rates.

    Main Results:

    Related Experiment Videos

    • 29 out of 36 patients presented with significant renal impairment, and 18 required dialysis.
    • 18 patients experienced rapid renal function recovery; two more recovered after dialysis.
    • No specific immunosuppressive regimen demonstrated a clear benefit; some patients recovered without immunosuppression.
    • Overall survival was 80% at 1 year and 64% at 5 years, which is better than previously reported, especially for an elderly cohort.

    Conclusions:

    • Renal vasculitis, including microPAN and Wegener's granulomatosis, has a better prognosis than previously thought, with potential for significant renal recovery.
    • The role and benefit of specific immunosuppressive therapies require further investigation, as recovery can occur even without immunosuppression.