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Albuminuria in Pediatric Patients With Adenotonsillar Hypertrophy

Ozlem Unsal1, Gulpembe Bozkurt, Meltem Esen Akpinar

  • 1*Sisli Hamidiye Etfal Training and Research Hospital, Clinic of Otorhinolaryngology & Head and Neck Surgery †Sisli Hamidiye Etfal Training and Research Hospital, Clinic of Biochemistry, Istanbul, Turkey.

The Journal of Craniofacial Surgery
|September 1, 2017
PubMed

Insights

This study found no link between intermittent nocturnal hypoxia and albuminuria in children with adenotonsillar hypertrophy. However, higher adenoid grades were associated with increased albuminuria, suggesting a potential inflammatory link.

Area of Science:

  • Pediatric Nephrology
  • Sleep Medicine
  • Otolaryngology

Background:

  • Adenotonsillar hypertrophy is common in children and can cause intermittent nocturnal hypoxia.
  • Albuminuria, a marker of kidney damage, has been linked to hypoxia in adults.
  • The relationship between hypoxia and albuminuria in pediatric adenotonsillar hypertrophy is not well-established.

Purpose of the Study:

  • To investigate the association between intermittent nocturnal hypoxia and albuminuria in pediatric patients with adenotonsillar hypertrophy.
  • To explore the relationship between adenoid grade and albuminuria in this population.

Main Methods:

  • Prospective study comparing children with severe adenotonsillar hypertrophy (study group) to those with mild hypertrophy or post-surgery (control group).
  • Nocturnal pulse oximetry was used to assess intermittent hypoxia.
  • Urine samples were analyzed for albuminuria on the day of surgery.

Main Results:

  • No statistically significant difference in albuminuria was found between the study and control groups.
  • No pulse oximetry parameters were statistically associated with albuminuria.
  • A significant association was observed between higher adenoid grade and the presence of albuminuria (P=0.011).

Conclusions:

  • Intermittent nocturnal hypoxia does not appear to be a significant factor for albuminuria in children with adenotonsillar hypertrophy.
  • Adenoid grade, however, shows a notable association with albuminuria, possibly due to inflammatory mediators affecting renal permeability.
  • Further research is needed to elucidate the mechanisms linking adenoid hypertrophy and renal changes in children.

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