Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

1.7K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spontaneous Acute Left-Sided Abdominal Pain in a Patient With AL Amyloidosis.

EJHaem·2026
Same author

Structured reasoning failures compromise LLM interpretation of clinical oncology notes.

NPJ digital medicine·2026
Same author

Real-World Safety, Efficacy, and Immune Recovery Following Out-of-Specification Ciltacabtagene Autoleucel in Multiple Myeloma.

Transplantation and cellular therapy·2026
Same author

Outcomes of acute myeloid leukemia patients admitted to the intensive care unit within 100 days of allogeneic hematopoietic stem cell transplantation.

The American journal of the medical sciences·2026
Same author

Bone-Modifying Agents in Metastatic Castration-Resistant Prostate Cancer.

JAMA network open·2026
Same author

Reply to: Prostate-Specific Membrane Antigen Positron Emission Tomography and Radiometabolic Therapies in Metastatic Castration-Resistant Prostate Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026

Related Experiment Video

Updated: Feb 23, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
05:32

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

7.3K

Bone lymphoma with multiple negative bone biopsies.

Irbaz Bin Riaz1, Muhammad Shahzeb Khan, Konstantin Mazursky

  • 1Irbaz bin Riaz practices in the Department of Internal Medicine at the University of Arizona in Tucson. Muhammad Shahzeb Khan practices at Dow University of Health Sciences in Karachi, Pakistan. Konstantin Mazursky practices in the Department of Internal Medicine at the University of Arizona. Muhammad Husnain practices in the Division of Cardiovascular Diseases, Department of Medicine, at the University of Arizona. Faiz Anwer practices in the Division of Hematology, Oncology, Blood, and Marrow Transplantation, Department of Medicine, at the University of Arizona. The authors have disclosed no potential conflicts of interest, financial or otherwise.

JAAPA : Official Journal of the American Academy of Physician Assistants
|September 1, 2017
PubMed
Summary

A 71-year-old man was diagnosed with bone lymphoma after initial tests for multiple myeloma were negative. The lymphoma presented with knee pain, azotemia, and hypercalcemia, confirmed by surgical biopsy.

More Related Videos

A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies
08:51

A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies

Published on: March 8, 2014

17.2K

Related Experiment Videos

Last Updated: Feb 23, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
05:32

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

7.3K
A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies
08:51

A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies

Published on: March 8, 2014

17.2K

Area of Science:

  • Oncology
  • Hematology
  • Orthopedic Oncology

Background:

  • Bone tumors can present with complex systemic symptoms.
  • Differential diagnosis of bone lesions requires comprehensive evaluation.
  • Mature B-cell neoplasms can involve bone tissue.

Observation:

  • A 71-year-old male presented with right knee pain, prerenal azotemia, and hypercalcemia.
  • Imaging revealed a distal femur mass.
  • Initial investigations, including bone marrow biopsy, did not confirm multiple myeloma.

Findings:

  • Open surgical biopsy confirmed lymphoma involving the bone.
  • Histologic findings were characteristic of a mature B-cell neoplasm of germinal cell origin.

Implications:

  • This case highlights the importance of considering lymphoma in the differential diagnosis of bone lesions, even when myeloma is initially suspected.
  • Surgical biopsy can be crucial for definitive diagnosis in complex cases.
  • Understanding the diverse presentations of B-cell neoplasms is vital for accurate patient management.