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Updated: Feb 23, 2026
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Ageing with HIV: do comorbidities and polymedication drive treatment optimization?
HIV Medicine
|September 1, 2017
Summary
Older HIV patients, particularly those with long-term infection, frequently experience comorbidities and polypharmacy. This highlights the need for tailored care strategies for the aging HIV population.
Area of Science:
- Gerontology
- Infectious Diseases
- Pharmacology
Background:
- The population of individuals living with HIV is aging globally.
- Understanding the health status and treatment patterns of older HIV-infected individuals is crucial for public health.
- This study focuses on the specific context of France in 2013.
Purpose of the Study:
- To describe the characteristics of aging HIV-infected individuals (over 50 years old) in France.
- To analyze their current antiretroviral therapy (ART), comorbidities, and co-prescriptions.
- To compare these factors with those of a younger HIV-infected population.
Main Methods:
- Retrospective analysis of a prospectively collected database.
- Comparison of patient characteristics, ART, comorbidities, and comedications between aging and younger HIV-infected cohorts.
- Categorization of aging patients into 'experienced aging' (diagnosed before 2000) and 'recently diagnosed aging' groups.
Main Results:
- 10,318 aging patients (median age 56) were compared to 13,302 younger patients (median age 42).
- Aging patients, especially the 'experienced aging' group, showed high prevalence of comorbidities (62.1%) and comedications (71%).
- Integrase strand transfer inhibitors (INSTIs) were more frequently used in patients with comorbidities and co-prescriptions.
Conclusions:
- Aging HIV-infected patients, particularly those with a long history of infection, exhibit a high prevalence of comorbidities.
- Polypharmacy, indicated by frequent co-prescriptions, is a significant issue in this population.
- These findings underscore the importance of managing complex health needs in the growing population of older adults living with HIV.
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